Sodium thirst in nephrectomized and nephrectomized-anosmic rats
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Extrarenal effects of intravenous pitressin in nephrectomized rats.
Using inulin as indicator of the extracellular fluid volume, the effects of Pitressin on the movements of sodium and potassium were studied in the nephrectomized rat together with simultaneously determined direct blood pressure values. Pitressin caused a movement of sodium and water into cells coupled with the extrusion of some potassium during the phase of blood pressure elevation. The beginni...
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Tubulointerstitial macrophage infiltration is a hallmark of chronic kidney disease involved in the progression of renal fibrosis. Pirfenidone is a newly identified antifibrotic drug, the potential mechanism of which remains unclear. The aim of this study was to investigate the effects of pirfenidone on M1/M2 macrophage infiltration in nephrectomized rats. Nephrectomized rats were treated with p...
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Reaction 1 is catalyzed by the enzyme arginine-glycine transamidinase (l), and Reaction 2 by guanidinoacetic acid methylpherase (2). Until recently, the only site of the enzyme transamidinase in mammals was thought to be the mammalian kidney (1, 3). In brief footnotes, Horner et al. (4) mentioned preliminary experiments which indicated that an enzyme which catalyzes the reversal of Reaction 1 i...
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Leptin is an adipocyte-secreted hormone that has effects on appetite and energy expenditure. Several studies have shown that end-stage renal disease results in elevated plasma leptin concentrations and that the kidney is responsible for most of leptin elimination in rodents. Leptin metabolism was investigated in rats that underwent unilateral nephrectomy to experimentally limit renal eliminatio...
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Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1). IRS-1 is also a substrate for different peptides and growth factors, and a transgenic mouse "knockout" for this protein does not have normal growth. However, the role of IRS-1 in kidney hypertrophy and/or hyperplasia was not investig...
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ژورنال
عنوان ژورنال: Psychonomic Science
سال: 1967
ISSN: 0033-3131
DOI: 10.3758/bf03332232